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Recent Publications

Roberts R.A., Sabalos C.M., Leblanc M.L., Martel R.R., Frutiger Y.M., Unger J.M., Botros I.W., Rounseville M.P., Seligmann B.E., Miller T.P., Grogan T.M., Rimsza L.M. (2007) “Quantitative nuclease protection assay in paraffin-embedded tissue replicates prognostic microarray gene expression in diffuse large-B-cell lymphoma”, Lab Invest. 87(10), 979-997.

Kris, R.M., Felder, S., Deyholos, M., Lambert, G.M., Hinton, J., Botros,I., Martel, R., Seligmann, B., Galbraith D.W. (2007) “High-Throughput, High-Sensitivity Analysis of Gene Expression in Arabidopsis”, Plant Physiology, 144, 1256-1266.

Sawada H., Taniguchi K., Takami K. (2006) “Improved toxicogenomic screening for drug-induced phospholipidosis using a multiplexed quantitative gene expression ArrayPlate assay”, Toxicol In Vitro. 20(8):1506-13

Martel, R.R., Rounseville, M.P., Botros, I.W. and Seligmann, B.E. (2004) “Array Formats” pp. 3-22 in “Microarray Technology and Its Applications”, ISBN: 3-540-22931-0, Müller, U.R. and Nicolau, D.V., Eds., Springer-Verlag, Heidelberg.

Martel, R. (2003) “Arrays of Possibilities”, Modern Drug Discovery (Published by The American Chemical Society), November 2003, 47-50.

Palfreyman M.G., Hook D.J., Klimczak L.J., Brockman J.A., Evans D.M., Altar C.A. (2002) “Novel directions in antipsychotic target identification using gene arrays” Curr Drug Targets CNS Neurol Disord. 1(2):227-38.

Martel, R.R., Botros, I.W., Rounseville, M.P., Hinton, J.P., Staples, R.R., Morales, D.A., Farmer, J.B., and Seligmann, B.E. (2002) “Multiplexed Screening Assay for mRNA Combining Nuclease Protection with Luminescent Array Detection”, Assay and Drug Development Technologies, 1(1), 61-71.

Martel, R.R., Rounseville, M.P., Botros, I.W. and Seligmann, B.E. (2002) “Multiplexed Chemiluminescent Assays in ArrayPlates for High-Throughput Measurement of Gene Expression”, Progress in Biomedical Optics and Imaging, 3(18), 35-43.

Martel, R.R., Rounseville, M.P., Botros, I.W., Kris, R., Felder, S. and Seligmann, B.E. (2002) “Multiplexed Molecular Profiling (MMP) Transcription Assay in ArrayPlates for High-Throughput Measurement of Gene Expression” pp. 549-564 in “Gene Cloning and Expression Technologies”, ISBN: 1-881299-20-1, Lu, Q. and Weiner, M., Eds., BioTechniques Press, Eaton Publishing, Westborough, MA.

 

Trademarks

Capella, Omix, qCustom, qFix, and qNPA are trademarks of High Throughput Genomics, Inc. For questions regarding the usage of the marks, please contact feedback@htgenomics.com . 

 

Presentations

Beyond_Genome FFPE_Sections 2006

BMS Hepatotox CHI presentation

Bristol Meyers Squibb Hepatotox CHI 2005 presentation

Equipment and Imager List 2-3-06

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Intellectual Property

HTG has intellectual properties associated with four advanced and innovative technologies including:

  • Universal Arrays
  • Quantitative Nuclease Protection Assay (qNPA™)
  • Array printing
  • Hybridization acceleration

Microarrays have transformed pharmaceutical research and development and life science research by allowing scientists to measure many different molecules in a single sample simultaneously.

Yet, while high-density microarrays have been valuable in identifying potential gene targets, their imprecision, cost, and the lack of consistency between the microarrays available from different vendors have limited their use for other aspects of drug discovery and diagnostics.

HTG’s ArrayPlate™ product is based on Universal Array IP, a technology that provides scientists, researchers and technicians with the flexibility to customize an ArrayPlate on the bench top using a simple reagent-addition protocol to measure a unique set of targets.

HTG technology combines the Universal Array with its quantitative Nuclease Protection Assay (qNPA) to provide clients with a breakthrough quantitative gene expression platform.  The ArrayPlate product, based on these two technologies, delivers the Universal Array’s flexibility and qNPA’s excellent sensitivity, quantitative accuracy, precision and multiplexed, high-sample throughput to significantly enhance gene expression measurement.